Endocrine Abstracts

It is now realized that the vascular endothelium is the key signal transducer for the disturbed vascular biology that drives atherogenesis. Endothelial dysfunction leads to a pro-coagulant, adhesive, proliferative constrictor phenotype. Inflammation, endothial dysfunction and structural arterial wall changes are already linked by the end of the first decade of life. Classical risk factor burden affects nitric oxide dependent endothelial function and novel influences such as me...